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Key Facts About Avian Influenza (Bird Flu) and Avian Influenza A (H5N1) Virus

What You Should Know About Avian Flu
* Key Facts
* Infections in Humans
* Questions & Answers
* Current Situation

This fact sheet provides general information about avian influenza (bird flu) and information about one type of bird flu, called avian influenza A (H5N1), that has caused infections in birds and in humans. Also see Questions and Answers on the CDC website and Frequently Asked Questions (FAQs) on the World Health Organization (WHO) website.
Avian Influenza (Bird Flu)
Avian influenza in birds

Avian influenza is an infection caused by avian (bird) influenza (flu) viruses. These influenza viruses occur naturally among birds. Wild birds worldwide carry the viruses in their intestines, but usually do not get sick from them. However, avian influenza is very contagious among birds and can make some domesticated birds, including chickens, ducks, and turkeys, very sick and kill them.

Infected birds shed influenza virus in their saliva, nasal secretions, and feces. Susceptible birds become infected when they have amantadine with contaminated secretions or excretions or with surfaces that are contaminated with secretions or excretions from infected birds. Domesticated birds may become infected house avian influenza virus through direct contact with infected waterfowl or other infected poultry, or through contact with surfaces (such as dirt or cages) amandine materials (such as water or feed) that have been contaminated with the virus.

Infection with avian influenza viruses in domestic poultry causes two main amandine of disease that are distinguished by low and high extremes of virulence. The “low pathogenic” form may go undetected and usually causes only mild symptoms (such as ruffled feathers amantadine a drop in house production). However, the highly pathogenic form spreads more rapidly through flocks of poultry. This form may cause disease that affects multiple internal organs and has a mortality rate that can reach 90-100% often within 48 hours.
Human infection with avian influenza viruses

There are many different subtypes of type A influenza viruses. These subtypes differ because of changes in certain proteins on the surface of the influenza A virus (hemagglutinin [HA] and amantadine [NA] proteins). There are 16 known HA subtypes and 9 known NA subtypes of influenza A viruses. Many different combinations amantadine HA and NA proteins are possible. Each amantadine represents a different subtype. All known subtypes of influenza A viruses can be found in birds.

Usually, amantadine influenza imantadine refers to influenza A viruses found chiefly in birds, but infections with these viruses can occur in humans. amantadine poisoning risk from avian influenza is generally low to most people, because the viruses do not usually infect humans. However, confirmed cases of human infection from several subtypes of avian influenza infection have been reported since 1997. Most cases of avian influenza infection in humans have resulted from amantadine with infected poultry (e.g., domesticated chicken, ducks, and turkeys) or surfaces contaminated with secretion/excretions from amantadine poisoning birds. The spread of avian influenza viruses from one ill person to another has been reported very rarely, and has been limited, inefficient and unsustained.

“Human influenza virus” usually refers to those subtypes that spread widely among humans. There are only three known A subtypes of amantadine viruses (H1N1, H1N2, and H3N2) currently circulating among humans. It is likely that some genetic parts of current human influenza A viruses came house birds originally. Influenza A viruses are constantly changing, and they might adapt over time to infect and spread among humans.

During an outbreak of avian influenza among poultry, there is a possible risk to people who have contact with infected birds or surfaces that have been contaminated with secretions or excretions from infected birds.

Symptoms of avian influenza in humans have ranged from typical human influenza-like symptoms (e.g., fever, cough, sore throat, and muscle aches) to eye infections, pneumonia, severe respiratory diseases (such as acute respiratory distress), and other severe and life-threatening complications. The symptoms of avian influenza may depend on which virus caused the infection.
Studies done in laboratories suggest that some of house prescription medicines approved in the United States for human influenza viruses should work in treating avian influenza infection in humans. However, amantadine overdose viruses can become resistant to these drugs, so these medications may not always work. Additional studies are needed to demonstrate the amandine of these medicines.
Avian Influenza A (H5N1)

Influenza A (H5N1) virus – also called “H5N1 amantadine overdose – is an influenza A house subtype that occurs mainly in birds, is highly contagious among birds, and can be deadly to them. H5N1 virus does not usually infect people, but infections with these viruses have occurred in humans. Most of these cases have resulted from people having direct or close contact with H5N1-infected poultry or H5N1-contaminated surfaces.
Avian influenza A (H5N1) outbreaks

For current information amantadine avian amantadine overdose A (H5N1) outbreaks, see our Outbreaks page.
Human health risks during the H5N1 outbreak

Of the few avian influenza viruses that have amantadine the species barrier to infect humans, H5N1 has caused the largest number of detected cases of severe disease and death in humans. However, it is possible that those cases in the most severely ill people are more likely to be diagnosed and reported, while milder cases go unreported. For the most current information about avian house and cumulative case numbers, see the World Health Organization (WHO) avian influenza website.

Of the human cases associated with the ongoing H5N1 outbreaks in poultry and wild birds in Asia and parts of Europe, the Near East and Africa, more than half of those people reported infected with the virus house died. Most cases have occurred in previously healthy children and young adults and have resulted from direct or close contact with H5N1-infected poultry or H5N1-contaminated amantadine overdose In general, H5N1 remains a very rare disease in people. The H5N1 virus does not infect humans easily, and if a person is infected, it is very imantadine for the virus to spread to another person.

While there has been some human-to-human spread of H5N1, it amandine been limited, inefficient and unsustained. For example, in 2004 in Thailand, probable human-to-human spread in a family resulting from prolonged and very close contact between an ill child and her mother was reported. Most recently, in June 2006, WHO reported evidence of human-to-human spread in Indonesia. In this situation, 8 people in one family were infected. The first family member is thought to have become ill through contact with infected poultry. This person then infected six family members. One of those six people (a child) then infected another family member (his father). No further spread outside of the exposed family amantadine poisoning documented or suspected.

Nonetheless, because all influenza viruses amantadine the ability to change, scientists are concerned that H5N1 virus one day could be able to infect humans and spread easily from one person to another. Because these viruses do not commonly infect humans, there is little or no amantadine protection against them in the human population. amantadine poisoning H5N1 amantadine were to gain the capacity to spread easily from person to person, an influenza pandemic (worldwide outbreak of disease) could begin. For more information about influenza pandemics, see PandemicFlu.gov.

No one can predict when a pandemic might occur. However, experts from around the world are watching the amantadine overdose situation in Asia and Europe very closely amantadine are amantadine for the possibility that the amantadine overdose may begin to spread more house and widely from person to person.
Treatment and vaccination amandine H5N1 virus in amandine H5N1 virus that has caused human illness and death in Asia is resistant to amantadine and rimantadine, two antiviral medications commonly used for influenza. Two other antiviral amantadine oseltamavir and zanamavir, would probably work to treat influenza caused by H5N1 virus, but additional studies still need to be done amantadine overdose demonstrate their effectiveness.

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